Keratin, type II cuticular Hb6 (KRT86)

About Keratin, type II cuticular Hb6

Keratin, type II cuticular Hb6 (KRT86) is a protein from Homo sapiens identified by UniProt accession O43790, 486 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Keratin, type II cuticular Hb6
UniProt accession	O43790
Gene	KRT86
Organism	Homo sapiens
Length	486 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

monilethrix · score 0.76
neurodegenerative disease · score 0.34
Alzheimer disease · score 0.34
lysosomal storage disease · score 0.34
multiple sclerosis · score 0.34
Parkinson disease · score 0.34
genetic disorder · score 0.19
glioblastoma multiforme · score 0.18
clear cell renal carcinoma · score 0.18
head and neck squamous cell carcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43790-F1	alphafold	PREDICTED	73.47	—

Amino-acid sequence (486 residues)

MTCGSYCGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR RLYEEEIRVL QSHISDTSVV VKLDNSRDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG VGSVNVCVSS SRGGVVCGDL CASTTAPVVS TRVSSVPSNS NVVVGTTNAC APSARVGVCG GSCKRC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards