About Cleavage and polyadenylation specificity factor subunit 5
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) is a protein
from Homo sapiens identified by UniProt accession
O43809, 227 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Cleavage and polyadenylation specificity factor subunit 5 |
|---|
| UniProt accession | O43809 |
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| Gene | NUDT21 |
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| Organism | Homo sapiens |
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| Length | 227 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- chronic lymphocytic leukemia · score 0.16
- urate measurement · score 0.15
- body mass index · score 0.13
- neoplasm · score 0.10
- high density lipoprotein cholesterol measurement · score 0.09
- cancer · score 0.09
- glioblastoma multiforme · score 0.09
- hepatocellular carcinoma · score 0.08
- breast cancer · score 0.08
- breast carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43809-F1 | alphafold | PREDICTED | 90.40 | — |
Amino-acid sequence (227 residues)
MSVVPPNRSQ TGWPRGVTQF GNKYIQQTKP LTLERTINLY PLTNYTFGTK EPLYEKDSSV AARFQRMREE FDKIGMRRTV EGVLIVHEHR LPHVLLLQLG TTFFKLPGGE LNPGEDEVEG LKRLMTEILG RQDGVLQDWV IDDCIGNWWR PNFEPPQYPY IPAHITKPKE HKKLFLVQLQ EKALFAVPKN YKLVAAPLFE LYDNAPGYGP IISSLPQLLS RFNFIYN
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