U3 small nucleolar RNA-interacting protein 2 (RRP9)

About U3 small nucleolar RNA-interacting protein 2

U3 small nucleolar RNA-interacting protein 2 (RRP9) is a protein from Homo sapiens identified by UniProt accession O43818, 475 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	U3 small nucleolar RNA-interacting protein 2
UniProt accession	O43818
Gene	RRP9
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
neoplasm · score 0.09
pachyonychia congenita · score 0.07
cancer · score 0.02
Keloid · score 0.02
pancreatic neoplasm · score 0.01
colorectal neoplasm · score 0.01
hepatocellular carcinoma · score 0.00
orthostatic intolerance · score 0.00
major depressive disorder · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43818-F1	alphafold	PREDICTED	83.41	—

Amino-acid sequence (475 residues)

MSATAAARKR GKPASGAGAG AGAGKRRRKA DSAGDRGKSK GGGKMNEEIS SDSESESLAP RKPEEEEEEE LEETAQEKKL RLAKLYLEQL RQQEEEKAEA RAFEEDQVAG RLKEDVLEQR GRLQKLVAKE IQAPASADIR VLRGHQLSIT CLVVTPDDSA IFSAAKDCSI IKWSVESGRK LHVIPRAKKG AEGKPPGHSS HVLCMAISSD GKYLASGDRS KLILIWEAQS CQHLYTFTGH RDAVSGLAFR RGTHQLYSTS HDRSVKVWNV AENSYVETLF GHQDAVAALD ALSRECCVTA GGRDGTVRVW KIPEESQLVF YGHQGSIDCI HLINEEHMVS GADDGSVALW GLSKKRPLAL QREAHGLRGE PGLEQPFWIS SVAALLNTDL VATGSHSSCV RLWQCGEGFR QLDLLCDIPL VGFINSLKFS SSGDFLVAGV GQEHRLGRWW RIKEARNSVC IIPLRRVPVP PAAGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards