Cytochrome c oxidase assembly factor SCO2 (SCO2)

About Cytochrome c oxidase assembly factor SCO2

Cytochrome c oxidase assembly factor SCO2 (SCO2) is a protein from Homo sapiens identified by UniProt accession O43819, 266 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	Cytochrome c oxidase assembly factor SCO2
UniProt accession	O43819
Gene	SCO2
Organism	Homo sapiens
Length	266 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1 · score 0.80
myopia 6 · score 0.79
fatal infantile encephalocardiomyopathy · score 0.75
Rare isolated myopia · score 0.69
mitochondrial DNA depletion syndrome 1 · score 0.56
neurodegenerative disease · score 0.50
mitochondrial neurogastrointestinal encephalomyopathy · score 0.48
genetic disorder · score 0.47
Leigh syndrome · score 0.37
Charcot-Marie-Tooth disease type 4 · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43819-F1	alphafold	PREDICTED	83.72	—

Amino-acid sequence (266 residues)

MLLLTRSPTA WHRLSQLKPR VLPGTLGGQA LHLRSWLLSR QGPAETGGQG QPQGPGLRTR LLITGLFGAG LGGAWLALRA EKERLQQQKR TEALRQAAVG QGDFHLLDHR GRARCKADFR GQWVLMYFGF THCPDICPDE LEKLVQVVRQ LEAEPGLPPV QPVFITVDPE RDDVEAMARY VQDFHPRLLG LTGSTKQVAQ ASHSYRVYYN AGPKDEDQDY IVDHSIAIYL LNPDGLFTDY YGRSRSAEQI SDSVRRHMAA FRSVLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards