Hyaluronidase-3 (HYAL3)

About Hyaluronidase-3

Hyaluronidase-3 (HYAL3) is a protein from Homo sapiens identified by UniProt accession O43820, 417 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Hyaluronidase-3
UniProt accession	O43820
Gene	HYAL3
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

basophil count · score 0.29
basophil percentage of leukocytes · score 0.26
blood protein measurement · score 0.17
body height · score 0.15
mean corpuscular hemoglobin · score 0.13
cutaneous melanoma · score 0.10
emphysema · score 0.06
reticulocyte count · score 0.06
familial spontaneous pneumothorax · score 0.05
neuroticism measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43820-F1	alphafold	PREDICTED	91.29	—

Amino-acid sequence (417 residues)

MTTQLGPALV LGVALCLGCG QPLPQVPERP FSVLWNVPSA HCEARFGVHL PLNALGIIAN RGQHFHGQNM TIFYKNQLGL YPYFGPRGTA HNGGIPQALP LDRHLALAAY QIHHSLRPGF AGPAVLDWEE WCPLWAGNWG RRRAYQAASW AWAQQVFPDL DPQEQLYKAY TGFEQAARAL MEDTLRVAQA LRPHGLWGFY HYPACGNGWH SMASNYTGRC HAATLARNTQ LHWLWAASSA LFPSIYLPPR LPPAHHQAFV RHRLEEAFRV ALVGHRHPLP VLAYVRLTHR RSGRFLSQDD LVQSIGVSAA LGAAGVVLWG DLSLSSSEEE CWHLHDYLVD TLGPYVINVT RAAMACSHQR CHGHGRCARR DPGQMEAFLH LWPDGSLGDW KSFSCHCYWG WAGPTCQEPR PGPKEAV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards