Cilia- and flagella-associated protein 410 (CFAP410)

About Cilia- and flagella-associated protein 410

Cilia- and flagella-associated protein 410 (CFAP410) is a protein from Homo sapiens identified by UniProt accession O43822, 256 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Cilia- and flagella-associated protein 410
UniProt accession	O43822
Gene	CFAP410
Organism	Homo sapiens
Length	256 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

axial spondylometaphyseal dysplasia · score 0.77
retinal dystrophy with or without macular staphyloma · score 0.73
Retinal dystrophy · score 0.51
retinitis pigmentosa · score 0.48
amyotrophic lateral sclerosis · score 0.46
Cone rod dystrophy · score 0.44
Amyotrophic lateral sclerosis · score 0.37
Leber congenital amaurosis · score 0.33
cone-rod dystrophy · score 0.29
cone dystrophy · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43822-F1	alphafold	PREDICTED	77.65	—

Amino-acid sequence (256 residues)

MKLTRKMVLT RAKASELHSV RKLNCWGSRL TDISICQEMP SLEVITLSVN SISTLEPVSR CQRLSELYLR RNRIPSLAEL FYLKGLPRLR VLWLAENPCC GTSPHRYRMT VLRTLPRLQK LDNQAVTEEE LSRALSEGEE ITAAPEREGT GHGGPKLCCT LSSLSSAAET GRDPLDSEEE ATSGAQDERG LKPPSRGQFP SLSARDASSS HRGRNVLTAI LLLLRELDAE GLEAVQQTVG SRLQALRGEE VQEHAE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards