About A-kinase anchor protein 8
A-kinase anchor protein 8 (AKAP8) is a protein
from Homo sapiens identified by UniProt accession
O43823, 692 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | A-kinase anchor protein 8 |
|---|
| UniProt accession | O43823 |
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| Gene | AKAP8 |
|---|
| Organism | Homo sapiens |
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| Length | 692 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (42)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- erythrocyte count · score 0.19
- cystatin C measurement · score 0.17
- mean corpuscular volume · score 0.08
- mean corpuscular hemoglobin · score 0.07
- mean corpuscular hemoglobin concentration · score 0.06
- red blood cell density measurement · score 0.06
- reticulocyte count · score 0.06
- cancer · score 0.05
- reticulocyte measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43823-F1 | alphafold | PREDICTED | 52.65 | — |
Amino-acid sequence (692 residues)
MDQGYGGYGA WSAGPANTQG AYGTGVASWQ GYENYNYYGA QNTSVTTGAT YSYGPASWEA AKANDGGLAA GAPAMHMASY GPEPCTDNSD SLIAKINQRL DMMSKEGGRG GSGGGGEGIQ DRESSFRFQP FESYDSRPCL PEHNPYRPSY SYDYEFDLGS DRNGSFGGQY SECRDPARER GSLDGFMRGR GQGRFQDRSN PGTFMRSDPF VPPAASSEPL STPWNELNYV GGRGLGGPSP SRPPPSLFSQ SMAPDYGVMG MQGAGGYDST MPYGCGRSQP RMRDRDRPKR RGFDRFGPDG TGRKRKQFQL YEEPDTKLAR VDSEGDFSEN DDAAGDFRSG DEEFKGEDEL CDSGRQRGEK EDEDEDVKKR REKQRRRDRT RDRAADRIQF ACSVCKFRSF DDEEIQKHLQ SKFHKETLRF ISTKLPDKTV EFLQEYIVNR NKKIEKRRQE LMEKETAKPK PDPFKGIGQE HFFKKIEAAH CLACDMLIPA QPQLLQRHLH SVDHNHNRRL AAEQFKKTSL HVAKSVLNNR HIVKMLEKYL KGEDPFTSET VDPEMEGDDN LGGEDKKETP EEVAADVLAE VITAAVRAVD GEGAPAPESS GEPAEDEGPT DTAEAGSDPQ AEQLLEEQVP CGTAHEKGVP KARSEAAEAG NGAETMAAEA ESAQTRVAPA PAAADAEVEQ TDAESKDAVP TE
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