Putative GTP-binding protein 6 (GTPBP6)

About Putative GTP-binding protein 6

Putative GTP-binding protein 6 (GTPBP6) is a protein from Homo sapiens identified by UniProt accession O43824, 516 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Putative GTP-binding protein 6
UniProt accession	O43824
Gene	GTPBP6
Organism	Homo sapiens
Length	516 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

influenza · score 0.01
infection · score 0.01
infect · score 0.01
Klinefelter's syndrome · score 0.01
schizophrenia · score 0.01
Granulocytopenia · score 0.00
Leri-Weill dyschondrosteosis · score 0.00
language impairment · score 0.00
Lyme disease · score 0.00
diphtheria · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43824-F1	alphafold	PREDICTED	77.46	—

Amino-acid sequence (516 residues)

MWALRAAVRP GLRLSRVGRG RSAPRAAAPS CPARALAAVG RRSPGNLEGP WGGGRGLRAD GGRSRTGDDE EEPEDADENA EEELLRGEPL LPAGTQRVCL VHPDVKWGPG KSQMTRAEWQ VAEATALVHT LDGWSVVQTM VVSTKTPDRK LIFGKGNFEH LTEKIRGSPD ITCVFLNVER MAAPTKKELE AAWGVEVFDR FTVVLHIFRC NARTKEARLQ VALAEMPLHR SNLKRDVAHL YRGVGSRYIM GSGESFMQLQ QRLLREKEAK IRKALDRLRK KRHLLRRQRT RREFPVISVV GYTNCGKTTL IKALTGDAAI QPRDQLFATL DVTAHAGTLP SRMTVLYVDT IGFLSQLPHG LIESFSATLE DVAHSDLILH VRDVSHPEAE LQKCSVLSTL RGLQLPAPLL DSMVEVHNKV DLVPGYSPTE PNVVPVSALR GHGLQELKAE LDAAVLKATG RQILTLRVRL AGAQLSWLYK EATVQEVDVI PEDGAADVRV IISNSAYGKF RKLFPG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards