Beta-1,3-galactosyltransferase 2 (B3GALT2)

About Beta-1,3-galactosyltransferase 2

Beta-1,3-galactosyltransferase 2 (B3GALT2) is a protein from Homo sapiens identified by UniProt accession O43825, 422 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Beta-1,3-galactosyltransferase 2
UniProt accession	O43825
Gene	B3GALT2
Organism	Homo sapiens
Length	422 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

peripheral vascular disease · score 0.18
PHF-tau measurement · score 0.16
familial isolated hyperparathyroidism · score 0.12
hyperparathyroidism · score 0.12
Beta blocking agent use measurement · score 0.09
lymphocyte count · score 0.08
chronotype measurement · score 0.07
lifestyle measurement · score 0.07
breast carcinoma · score 0.06
Diuretic use measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43825-F1	alphafold	PREDICTED	78.56	—

Amino-acid sequence (422 residues)

MLQWRRRHCC FAKMTWNAKR SLFRTHLIGV LSLVFLFAMF LFFNHHDWLP GRAGFKENPV TYTFRGFRST KSETNHSSLR NIWKETVPQT LRPQTATNSN NTDLSPQGVT GLENTLSANG SIYNEKGTGH PNSYHFKYII NEPEKCQEKS PFLILLIAAE PGQIEARRAI RQTWGNESLA PGIQITRIFL LGLSIKLNGY LQRAILEESR QYHDIIQQEY LDTYYNLTIK TLMGMNWVAT YCPHIPYVMK TDSDMFVNTE YLINKLLKPD LPPRHNYFTG YLMRGYAPNR NKDSKWYMPP DLYPSERYPV FCSGTGYVFS GDLAEKIFKV SLGIRRLHLE DVYVGICLAK LRIDPVPPPN EFVFNHWRVS YSSCKYSHLI TSHQFQPSEL IKYWNHLQQN KHNACANAAK EKAGRYRHRK LH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards