About Zinc finger and BTB domain-containing protein 14
Zinc finger and BTB domain-containing protein 14 (ZBTB14) is a protein
from Homo sapiens identified by UniProt accession
O43829, 449 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 14 |
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| UniProt accession | O43829 |
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| Gene | ZBTB14 |
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| Organism | Homo sapiens |
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| Length | 449 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- intelligence · score 0.29
- stroke · score 0.11
- smoking behavior · score 0.07
- type 2 diabetes mellitus · score 0.07
- Heterotaxia · score 0.05
- megabladder, congenital · score 0.04
- body height · score 0.04
- genito-palato-cardiac syndrome · score 0.04
- fallot complex-intellectual disability-growth delay syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43829-F1 | alphafold | PREDICTED | 51.86 | — |
Amino-acid sequence (449 residues)
MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH RCVLAACSTY FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV KKEDVNLMMS SGQILGIRFL DKLCSQKRDV SSPDENNGQS KSKYCLKINR PIGDAADTQD DDVEEIGDQD DSPSDDTVEG TPPSQEDGKS PTTTLRVQEA ILKELGSEEV RKVNCYGQEV ESMETPESKD LGSQTPQALT FNDGMSEVKD EQTPGWTTAA SDMKFEYLLY GHHREQIACQ ACGKTFSDEG RLRKHEKLHT ADRPFVCEMC TKGFTTQAHL KEHLKIHTGY KPYSCEVCGK SFIRAPDLKK HERVHSNERP FACHMCDKAF KHKSHLKDHE RRHRGEKPFV CGSCTKAFAK ASDLKRHENN MHSERKQVTP SAIQSETEQL QAAAMAAEAE QQLETIACS
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