About Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (IDH3B) is a protein
from Homo sapiens identified by UniProt accession
O43837, 385 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial |
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| UniProt accession | O43837 |
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| Gene | IDH3B |
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| Organism | Homo sapiens |
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| Length | 385 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (111)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.68
- Posterior column ataxia - retinitis pigmentosa · score 0.40
- neurodegenerative disease · score 0.35
- Retinal dystrophy · score 0.18
- attention deficit hyperactivity disorder · score 0.07
- azoospermia · score 0.06
- attention deficit-hyperactivity disorder 8 · score 0.05
- schizophrenia 15 · score 0.05
- Tourette syndrome · score 0.05
- Familial exudative vitreoretinopathy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43837-F1 | alphafold | PREDICTED | 87.80 | — |
Amino-acid sequence (385 residues)
MAALSGVRWL TRALVSAGNP GAWRGLSTSA AAHAASRSQA EDVRVEGSFP VTMLPGDGVG PELMHAVKEV FKAAAVPVEF QEHHLSEVQN MASEEKLEQV LSSMKENKVA IIGKIHTPME YKGELASYDM RLRRKLDLFA NVVHVKSLPG YMTRHNNLDL VIIREQTEGE YSSLEHESAR GVIECLKIVT RAKSQRIAKF AFDYATKKGR GKVTAVHKAN IMKLGDGLFL QCCEEVAELY PKIKFETMII DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK KVIKVGKVRT RDMGGYSTTT DFIKSVIGHL QTKGS
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