About S-adenosylhomocysteine hydrolase-like protein 1
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) is a protein
from Homo sapiens identified by UniProt accession
O43865, 530 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | S-adenosylhomocysteine hydrolase-like protein 1 |
|---|
| UniProt accession | O43865 |
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| Gene | AHCYL1 |
|---|
| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (77)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- breast adenocarcinoma · score 0.28
- endometrial cancer · score 0.26
- lung adenocarcinoma · score 0.21
- head and neck squamous cell carcinoma · score 0.21
- ovarian cancer · score 0.18
- mathematical ability · score 0.17
- gastric carcinoma · score 0.15
- body height · score 0.15
- macrophage colony stimulating factor measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43865-F1 | alphafold | PREDICTED | 85.27 | — |
Amino-acid sequence (530 residues)
MSMPDAMPLP GVGEELKQAK EIEDAEKYSF MATVTKAPKK QIQFADDMQE FTKFPTKTGR RSLSRSISQS STDSYSSAAS YTDSSDDEVS PREKQQTNSK GSSNFCVKNI KQAEFGRREI EIAEQDMSAL ISLRKRAQGE KPLAGAKIVG CTHITAQTAV LIETLCALGA QCRWSACNIY STQNEVAAAL AEAGVAVFAW KGESEDDFWW CIDRCVNMDG WQANMILDDG GDLTHWVYKK YPNVFKKIRG IVEESVTGVH RLYQLSKAGK LCVPAMNVND SVTKQKFDNL YCCRESILDG LKRTTDVMFG GKQVVVCGYG EVGKGCCAAL KALGAIVYIT EIDPICALQA CMDGFRVVKL NEVIRQVDVV ITCTGNKNVV TREHLDRMKN SCIVCNMGHS NTEIDVTSLR TPELTWERVR SQVDHVIWPD GKRVVLLAEG RLLNLSCSTV PTFVLSITAT TQALALIELY NAPEGRYKQD VYLLPKKMDE YVASLHLPSF DAHLTELTDD QAKYLGLNKN GPFKPNYYRY
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