About Sodium/nucleoside cotransporter 2
Sodium/nucleoside cotransporter 2 (SLC28A2) is a protein
from Homo sapiens identified by UniProt accession
O43868, 658 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Sodium/nucleoside cotransporter 2 |
|---|
| UniProt accession | O43868 |
|---|
| Gene | SLC28A2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 658 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (46)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.16
- urinary metabolite measurement · score 0.12
- cutaneous melanoma · score 0.12
- phosphatidylcholine ether measurement · score 0.11
- serum metabolite measurement · score 0.09
- cortical thickness · score 0.09
- Barrett's esophagus · score 0.07
- renal system measurement · score 0.06
- esophageal adenocarcinoma · score 0.04
- Crohn's disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43868-F1 | alphafold | PREDICTED | 82.09 | — |
Amino-acid sequence (658 residues)
MEKASGRQSI ALSTVETGTV NPGLELMEKE VEPEGSKRTD AQGHSLGDGL GPSTYQRRSR WPFSKARSFC KTHASLFKKI LLGLLCLAYA AYLLAACILN FQRALALFVI TCLVIFVLVH SFLKKLLGKK LTRCLKPFEN SRLRLWTKWV FAGVSLVGLI LWLALDTAQR PEQLIPFAGI CMFILILFAC SKHHSAVSWR TVFSGLGLQF VFGILVIRTD LGYTVFQWLG EQVQIFLNYT VAGSSFVFGD TLVKDVFAFQ ALPIIIFFGC VVSILYYLGL VQWVVQKVAW FLQITMGTTA TETLAVAGNI FVGMTEAPLL IRPYLGDMTL SEIHAVMTGG FATISGTVLG AFIAFGVDAS SLISASVMAA PCALASSKLA YPEVEESKFK SEEGVKLPRG KERNVLEAAS NGAVDAIGLA TNVAANLIAF LAVLAFINAA LSWLGELVDI QGLTFQVICS YLLRPMVFMM GVEWTDCPMV AEMVGIKFFI NEFVAYQQLS QYKNKRLSGM EEWIEGEKQW ISVRAEIITT FSLCGFANLS SIGITLGGLT SIVPHRKSDL SKVVVRALFT GACVSLISAC MAGILYVPRG AEADCVSFPN TSFTNRTYET YMCCRGLFQS TSLNGTNPPS FSGPWEDKEF SAMALTNCCG FYNNTVCA
Explore Sodium/nucleoside cotransporter 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets