About Cyclic AMP-responsive element-binding protein 3
Cyclic AMP-responsive element-binding protein 3 (CREB3) is a protein
from Homo sapiens identified by UniProt accession
O43889, 371 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Cyclic AMP-responsive element-binding protein 3 |
|---|
| UniProt accession | O43889 |
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| Gene | CREB3 |
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| Organism | Homo sapiens |
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| Length | 371 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (62)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- cystatin C measurement · score 0.20
- breast ductal adenocarcinoma · score 0.11
- neuroimaging measurement · score 0.10
- brain measurement · score 0.08
- Red cell distribution width · score 0.08
- brain volume measurement · score 0.08
- hepatocellular carcinoma · score 0.08
- glioblastoma · score 0.07
- type 2 diabetes mellitus · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43889-F1 | alphafold | PREDICTED | 60.73 | — |
Amino-acid sequence (371 residues)
MELELDAGDQ DLLAFLLEES GDLGTAPDEA VRAPLDWALP LSEVPSDWEV DDLLCSLLSP PASLNILSSS NPCLVHHDHT YSLPRETVSM DLESESCRKE GTQMTPQHME ELAEQEIARL VLTDEEKSLL EKEGLILPET LPLTKTEEQI LKRVRRKIRN KRSAQESRRK KKVYVGGLES RVLKYTAQNM ELQNKVQLLE EQNLSLLDQL RKLQAMVIEI SNKTSSSSTC ILVLLVSFCL LLVPAMYSSD TRGSLPAEHG VLSRQLRALP SEDPYQLELP ALQSEVPKDS THQWLDGSDC VLQAPGNTSC LLHYMPQAPS AEPPLEWPFP DLFSEPLCRG PILPLQANLT RKGGWLPTGS PSVILQDRYS G
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