About Xaa-Pro aminopeptidase 2
Xaa-Pro aminopeptidase 2 (XPNPEP2) is a protein
from Homo sapiens identified by UniProt accession
O43895, 674 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Xaa-Pro aminopeptidase 2 |
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| UniProt accession | O43895 |
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| Gene | XPNPEP2 |
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| Organism | Homo sapiens |
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| Length | 674 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- angioedema · score 0.43
- acquired angioedema · score 0.21
- primary ovarian insufficiency · score 0.12
- acute myeloid leukemia · score 0.09
- myelodysplastic syndrome · score 0.07
- clear cell renal carcinoma · score 0.06
- Crohn's disease · score 0.05
- neoplasm · score 0.05
- Barrett's esophagus · score 0.05
- pancreatic carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43895-F1 | alphafold | PREDICTED | 91.58 | — |
Amino-acid sequence (674 residues)
MARAHWGCCP WLVLLCACAW GHTKPVDLGG QDVRNCSTNP PYLPVTVVNT TMSLTALRQQ MQTQNLSAYI IPGTDAHMNE YIGQHDERRA WITGFTGSAG TAVVTMKKAA VWTDSRYWTQ AERQMDCNWE LHKEVGTTPI VTWLLTEIPA GGRVGFDPFL LSIDTWESYD LALQGSNRQL VSITTNLVDL VWGSERPPVP NQPIYALQEA FTGSTWQEKV SGVRSQMQKH QKVPTAVLLS ALEETAWLFN LRASDIPYNP FFYSYTLLTD SSIRLFANKS RFSSETLSYL NSSCTGPMCV QIEDYSQVRD SIQAYSLGDV RIWIGTSYTM YGIYEMIPKE KLVTDTYSPV MMTKAVKNSK EQALLKASHV RDAVAVIRYL VWLEKNVPKG TVDEFSGAEI VDKFRGEEQF SSGPSFETIS ASGLNAALAH YSPTKELNRK LSSDEMYLLD SGGQYWDGTT DITRTVHWGT PSAFQKEAYT RVLIGNIDLS RLIFPAATSG RMVEAFARRA LWDAGLNYGH GTGHGIGNFL CVHEWPVGFQ SNNIAMAKGM FTSIEPGYYK DGEFGIRLED VALVVEAKTK YPGSYLTFEV VSFVPYDRNL IDVSLLSPEH LQYLNRYYQT IREKVGPELQ RRQLLEEFEW LQQHTEPLAA RAPDTASWAS VLVVSTLAIL GWSV
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