About Prickle planar cell polarity protein 3
Prickle planar cell polarity protein 3 (PRICKLE3) is a protein
from Homo sapiens identified by UniProt accession
O43900, 615 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Prickle planar cell polarity protein 3 |
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| UniProt accession | O43900 |
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| Gene | PRICKLE3 |
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| Organism | Homo sapiens |
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| Length | 615 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- Leber hereditary optic neuropathy · score 0.19
- Progressive sensorineural hearing impairment · score 0.11
- Familial exudative vitreoretinopathy · score 0.06
- X-linked retinal dysplasia · score 0.06
- Familial drusen · score 0.05
- X-linked retinoschisis · score 0.05
- retinitis pigmentosa · score 0.05
- severe early-childhood-onset retinal dystrophy · score 0.04
- exudative vitreoretinopathy 2, X-linked · score 0.04
- birdshot chorioretinopathy · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43900-F1 | alphafold | PREDICTED | 67.30 | — |
Amino-acid sequence (615 residues)
MFARGSRRRR SGRAPPEAED PDRGQPCNSC REQCPGFLLH GWRKICQHCK CPREEHAVHA VPVDLERIMC RLISDFQRHS ISDDDSGCAS EEYAWVPPGL KPEQVYQFFS CLPEDKVPYV NSPGEKYRIK QLLHQLPPHD SEAQYCTALE EEEKKELRAF SQQRKRENLG RGIVRIFPVT ITGAICEECG KQIGGGDIAV FASRAGLGAC WHPQCFVCTT CQELLVDLIY FYHVGKVYCG RHHAECLRPR CQACDEIIFS PECTEAEGRH WHMDHFCCFE CEASLGGQRY VMRQSRPHCC ACYEARHAEY CDGCGEHIGL DQGQMAYEGQ HWHASDRCFC CSRCGRALLG RPFLPRRGLI FCSRACSLGS EPTAPGPSRR SWSAGPVTAP LAASTASFSA VKGASETTTK GTSTELAPAT GPEEPSRFLR GAPHRHSMPE LGLRSVPEPP PESPGQPNLR PDDSAFGRQS TPRVSFRDPL VSEGGPRRTL SAPPAQRRRP RSPPPRAPSR RRHHHHNHHH HHNRHPSRRR HYQCDAGSGS DSESCSSSPS SSSSESSEDD GFFLGERIPL PPHLCRPMPA QDTAMETFNS PSLSLPRDSR AGMPRQARDK NCIVA
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