Growth arrest-specific protein 2 (GAS2)

About Growth arrest-specific protein 2

Growth arrest-specific protein 2 (GAS2) is a protein from Homo sapiens identified by UniProt accession O43903, 313 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.

Target properties

Protein name	Growth arrest-specific protein 2
UniProt accession	O43903
Gene	GAS2
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (117)

Diseases linked to this target (Open Targets).

Fanconi anemia · score 0.54
Fanconi anemia complementation group F · score 0.52
platelet count · score 0.25
breast adenocarcinoma · score 0.25
smoking status measurement · score 0.24
low grade glioma · score 0.23
ovarian cancer · score 0.23
endometrial cancer · score 0.23
mean arterial pressure · score 0.23
systolic blood pressure · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43903-F1	alphafold	PREDICTED	80.13	—

Amino-acid sequence (313 residues)

MCTALSPKVR SGPGLSDMHQ YSQWLASRHE ANLLPMKEDL ALWLTNLLGK EITAETFMEK LDNGALLCQL AETMQEKFKE SMDANKPTKN LPLKKIPCKT SAPSGSFFAR DNTANFLSWC RDLGVDETCL FESEGLVLHK QPREVCLCLL ELGRIAARYG VEPPGLIKLE KEIEQEETLS APSPSPSPSS KSSGKKSTGN LLDDAVKRIS EDPPCKCPNK FCVERLSQGR YRVGEKILFI RMLHNKHVMV RVGGGWETFA GYLLKHDPCR MLQISRVDGK TSPIQSKSPT LKDMNPDNYL VVSASYKAKK EIK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards