About NKG2-F type II integral membrane protein
NKG2-F type II integral membrane protein (KLRC4) is a protein
from Homo sapiens identified by UniProt accession
O43908, 158 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | NKG2-F type II integral membrane protein |
|---|
| UniProt accession | O43908 |
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| Gene | KLRC4 |
|---|
| Organism | Homo sapiens |
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| Length | 158 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (117)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- aspartate aminotransferase measurement · score 0.25
- serum alanine aminotransferase measurement · score 0.20
- monocyte count · score 0.17
- total blood protein measurement · score 0.14
- neutrophil percentage of leukocytes · score 0.14
- platelet crit · score 0.11
- mean corpuscular hemoglobin · score 0.09
- serum non-albumin protein measurement · score 0.08
- mean corpuscular volume · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43908-F1 | alphafold | PREDICTED | 60.26 | — |
Amino-acid sequence (158 residues)
MNKQRGTYSE VSLAQDPKRQ QRKLKGNKIS ISGTKQEIFQ VELNLQNASS DHQGNDKTYH CKGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPCIGVL EQNNFSLNRR MQKARHCGHC PEEWITYSNS CYYIGKERRT WEERVCWPVL RRTLICFL
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