Vascular endothelial growth factor D (VEGFD)

About Vascular endothelial growth factor D

Vascular endothelial growth factor D (VEGFD) is a protein from Homo sapiens identified by UniProt accession O43915, 354 residues long. MolForge cross-references it against 0 known binders and 324 disease associations.

Target properties

Protein name	Vascular endothelial growth factor D
UniProt accession	O43915
Gene	VEGFD
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (324)

Diseases linked to this target (Open Targets).

neoplasm · score 0.11
lymphangioleiomyomatosis · score 0.10
lung adenocarcinoma · score 0.09
chronic kidney disease · score 0.07
bulimia nervosa · score 0.07
chondrosarcoma · score 0.06
breast carcinoma · score 0.06
tuberous sclerosis · score 0.05
non-small cell lung carcinoma · score 0.05
gonorrhea · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43915-F1	alphafold	PREDICTED	70.55	—

Amino-acid sequence (354 residues)

MYREWVVVNV FMMLYVQLVQ GSSNEHGPVK RSSQSTLERS EQQIRAASSL EELLRITHSE DWKLWRCRLR LKSFTSMDSR SASHRSTRFA ATFYDIETLK VIDEEWQRTQ CSPRETCVEV ASELGKSTNT FFKPPCVNVF RCGGCCNEES LICMNTSTSY ISKQLFEISV PLTSVPELVP VKVANHTGCK CLPTAPRHPY SIIRRSIQIP EEDRCSHSKK LCPIDMLWDS NKCKCVLQEE NPLAGTEDHS HLQEPALCGP HMMFDEDRCE CVCKTPCPKD LIQHPKNCSC FECKESLETC CQKHKLFHPD TCSCEDRCPF HTRPCASGKT ACAKHCRFPK EKRAAQGPHS RKNP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards