Carbohydrate sulfotransferase 1 (CHST1)

About Carbohydrate sulfotransferase 1

Carbohydrate sulfotransferase 1 (CHST1) is a protein from Homo sapiens identified by UniProt accession O43916, 411 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Carbohydrate sulfotransferase 1
UniProt accession	O43916
Gene	CHST1
Organism	Homo sapiens
Length	411 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.33
gut microbiome measurement · score 0.31
Abnormality of refraction · score 0.30
type 2 diabetes mellitus · score 0.14
mathematical ability · score 0.11
body mass index · score 0.09
insomnia measurement · score 0.06
age at menarche · score 0.05
neutropenia, severe congenital, 2, autosomal dominant · score 0.04
combined immunodeficiency with skin granulomas · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43916-F1	alphafold	PREDICTED	87.43	—

Amino-acid sequence (411 residues)

MQCSWKAVLL LALASIAIQY TAIRTFTAKS FHTCPGLAEA GLAERLCEES PTFAYNLSRK THILILATTR SGSSFVGQLF NQHLDVFYLF EPLYHVQNTL IPRFTQGKSP ADRRVMLGAS RDLLRSLYDC DLYFLENYIK PPPVNHTTDR IFRRGASRVL CSRPVCDPPG PADLVLEEGD CVRKCGLLNL TVAAEACRER SHVAIKTVRV PEVNDLRALV EDPRLNLKVI QLVRDPRGIL ASRSETFRDT YRLWRLWYGT GRKPYNLDVT QLTTVCEDFS NSVSTGLMRP PWLKGKYMLV RYEDLARNPM KKTEEIYGFL GIPLDSHVAR WIQNNTRGDP TLGKHKYGTV RNSAATAEKW RFRLSYDIVA FAQNACQQVL AQLGYKIAAS EEELKNPSVS LVEERDFRPF S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards