About Autoimmune regulator
Autoimmune regulator (AIRE) is a protein
from Homo sapiens identified by UniProt accession
O43918, 545 residues long.
MolForge cross-references it against 0 known binders and
502 disease associations.
Target properties
| Protein name | Autoimmune regulator |
|---|
| UniProt accession | O43918 |
|---|
| Gene | AIRE |
|---|
| Organism | Homo sapiens |
|---|
| Length | 545 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (502)
Diseases linked to this target (Open Targets).
- Autoimmune polyendocrinopathy type 1 · score 0.85
- autoimmune polyendocrine syndrome type 1 · score 0.85
- type 1 diabetes mellitus · score 0.45
- neurodegenerative disease · score 0.43
- autoimmune polyendocrinopathy · score 0.38
- X-linked adrenal hypoplasia congenita · score 0.37
- alternating hemiplegia of childhood · score 0.37
- familial isolated hypoparathyroidism due to impaired PTH secretion · score 0.37
- diabetic retinopathy · score 0.30
- complication · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43918-F1 | alphafold | PREDICTED | 61.17 | — |
Amino-acid sequence (545 residues)
MATDAALRRL LRLHRTEIAV AVDSAFPLLH ALADHDVVPE DKFQETLHLK EKEGCPQAFH ALLSWLLTQD STAILDFWRV LFKDYNLERY GRLQPILDSF PKDVDLSQPR KGRKPPAVPK ALVPPPRLPT KRKASEEARA AAPAALTPRG TASPGSQLKA KPPKKPESSA EQQRLPLGNG IQTMSASVQR AVAMSSGDVP GARGAVEGIL IQQVFESGGS KKCIQVGGEF YTPSKFEDSG SGKNKARSSS GPKPLVRAKG AQGAAPGGGE ARLGQQGSVP APLALPSDPQ LHQKNEDECA VCRDGGELIC CDGCPRAFHL ACLSPPLREI PSGTWRCSSC LQATVQEVQP RAEEPRPQEP PVETPLPPGL RSAGEEVRGP PGEPLAGMDT TLVYKHLPAP PSAAPLPGLD SSALHPLLCV GPEGQQNLAP GARCGVCGDG TDVLRCTHCA AAFHWRCHFP AGTSRPGTGL RCRSCSGDVT PAPVEGVLAP SPARLAPGPA KDDTASHEPA LHRDDLESLL SEHTFDGILQ WAIQSMARPA APFPS
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