NADH dehydrogenase [ubiquinone] iron-sulfur protein…

About NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (NDUFS5) is a protein from Homo sapiens identified by UniProt accession O43920, 106 residues long. MolForge cross-references it against 0 known binders and 244 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
UniProt accession	O43920
Gene	NDUFS5
Organism	Homo sapiens
Length	106 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (244)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.60
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58
gestational diabetes · score 0.58
neurodegenerative disease · score 0.57
obesity · score 0.57
prediabetes syndrome · score 0.56
schizophrenia · score 0.55
multiple sclerosis · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43920-F1	alphafold	PREDICTED	94.40	—

Amino-acid sequence (106 residues)

MPFLDIQKRF GLNIDRWLTI QSGEQPYKMA GRCHAFEKEW IECAHGIGYT RAEKECKIEY DDFVECLLRQ KTMRRAGTIR KQRDKLIKEG KYTPPPHHIG KGEPRP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (NDUFS5)