Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic…

About Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) is a protein from Homo sapiens identified by UniProt accession O43924, 150 residues long. MolForge cross-references it against 0 known binders and 172 disease associations.

Target properties

Protein name	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
UniProt accession	O43924
Gene	PDE6D
Organism	Homo sapiens
Length	150 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (172)

Diseases linked to this target (Open Targets).

Joubert syndrome with orofaciodigital defect · score 0.62
coronary artery disease · score 0.55
stroke · score 0.55
Hepatitis, Alcoholic · score 0.48
diabetic nephropathy · score 0.47
chronic kidney disease · score 0.47
Myocardial Ischemia · score 0.47
diabetes mellitus · score 0.46
non-alcoholic steatohepatitis · score 0.45
cardiovascular disease · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43924-F1	alphafold	PREDICTED	96.23	—

Amino-acid sequence (150 residues)

MSAKDERARE ILRGFKLNWM NLRDAETGKI LWQGTEDLSV PGVEHEARVP KKILKCKAVS RELNFSSTEQ MEKFRLEQKV YFKGQCLEEW FFEFGFVIPN STNTWQSLIE AAPESQMMPA SVLTGNVIIE TKFFDDDLLV STSRVRLFYV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D)