UNC93-like protein MFSD11 (MFSD11)

About UNC93-like protein MFSD11

UNC93-like protein MFSD11 (MFSD11) is a protein from Homo sapiens identified by UniProt accession O43934, 449 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	UNC93-like protein MFSD11
UniProt accession	O43934
Gene	MFSD11
Organism	Homo sapiens
Length	449 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

acute myeloid leukemia · score 0.33
atypical chronic myeloid leukemia, BCR-ABL1 negative · score 0.33
acute megakaryoblastic leukemia in down syndrome · score 0.27
PHF-tau measurement · score 0.26
eye measurement · score 0.21
mathematical ability · score 0.07
alkaline phosphatase measurement · score 0.03
neutrophil count · score 0.03
esophageal squamous cell carcinoma · score 0.01
Dravet syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43934-F1	alphafold	PREDICTED	87.74	—

Amino-acid sequence (449 residues)

MSPESKKLFN IIILGVAFMF MFTAFQTCGN VAQTVIRSLN RTDFHGSGYT SMAIIYGVFS ASNLITPSVV AIVGPQLSMF ASGLFYSMYI AVFIQPFPWS FYTASVFIGI AAAVLWTAQG NCLTINSDEH SIGRNSGIFW ALLQSSLFFG NLYIYFAWQG KTQISESDRR TVFIALTVIS LVGTVLFFLI RKPDSENVLG EDESSDDQDM EVNESAQNNL TKAVDAFKKS FKLCVTKEML LLSITTAYTG LELTFFSGVY GTCIGATNKF GAEEKSLIGL SGIFIGIGEI LGGSLFGLLS KNNRFGRNPV VLLGILVHFI AFYLIFLNMP GDAPIAPVKG TDSSAYIKSS KEVAILCSFL LGLGDSCFNT QLLSILGFLY SEDSAPAFAI FKFVQSICAA VAFFYSNYLL LHWQLLVMVI FGFFGTISFF TVEWEAAAFV ARGSDYRSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards