About Double-strand-break repair protein rad21 homolog
Double-strand-break repair protein rad21 homolog (RAD21) is a protein
from Homo sapiens identified by UniProt accession
O60216, 631 residues long.
MolForge cross-references it against 0 known binders and
271 disease associations.
Target properties
| Protein name | Double-strand-break repair protein rad21 homolog |
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| UniProt accession | O60216 |
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| Gene | RAD21 |
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| Organism | Homo sapiens |
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| Length | 631 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (271)
Diseases linked to this target (Open Targets).
- Cornelia de Lange syndrome · score 0.77
- Mungan syndrome · score 0.58
- acute myeloid leukemia · score 0.48
- neurodegenerative disease · score 0.45
- genetic disorder · score 0.41
- lung carcinoma · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- Hepatobiliary Neoplasm · score 0.37
- bile duct carcinoma · score 0.37
- Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60216-F1 | alphafold | PREDICTED | 61.22 | — |
Amino-acid sequence (631 residues)
MFYAHFVLSK RGPLAKIWLA AHWDKKLTKA HVFECNLESS VESIISPKVK MALRTSGHLL LGVVRIYHRK AKYLLADCNE AFIKIKMAFR PGVVDLPEEN REAAYNAITL PEEFHDFDQP LPDLDDIDVA QQFSLNQSRV EEITMREEVG NISILQENDF GDFGMDDREI MREGSAFEDD DMLVSTTTSN LLLESEQSTS NLNEKINHLE YEDQYKDDNF GEGNDGGILD DKLISNNDGG IFDDPPALSE AGVMLPEQPA HDDMDEDDNV SMGGPDSPDS VDPVEPMPTM TDQTTLVPNE EEAFALEPID ITVKETKAKR KRKLIVDSVK ELDSKTIRAQ LSDYSDIVTT LDLAPPTKKL MMWKETGGVE KLFSLPAQPL WNNRLLKLFT RCLTPLVPED LRKRRKGGEA DNLDEFLKEF ENPEVPREDQ QQQHQQRDVI DEPIIEEPSR LQESVMEASR TNIDESAMPP PPPQGVKRKA GQIDPEPVMP PQQVEQMEIP PVELPPEEPP NICQLIPELE LLPEKEKEKE KEKEDDEEEE DEDASGGDQD QEERRWNKRT QQMLHGLQRA LAKTGAESIS LLELCRNTNR KQAAAKFYSF LVLKKQQAIE LTQEEPYSDI IATPGPRFHI I
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