Mitochondrial import inner membrane translocase…

About Mitochondrial import inner membrane translocase subunit Tim8 A

Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) is a protein from Homo sapiens identified by UniProt accession O60220, 97 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.

Target properties

Protein name	Mitochondrial import inner membrane translocase subunit Tim8 A
UniProt accession	O60220
Gene	TIMM8A
Organism	Homo sapiens
Length	97 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (140)

Diseases linked to this target (Open Targets).

Mohr-Tranebjaerg syndrome · score 0.82
deafness dystonia syndrome · score 0.69
hearing loss · score 0.37
genetic disorder · score 0.27
auditory neuropathy · score 0.27
breast cancer · score 0.07
cancer · score 0.06
dehydrated hereditary stomatocytosis · score 0.04
Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
hemolytic anemia due to erythrocyte adenosine deaminase overproduction · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60220-F1	alphafold	PREDICTED	85.47	—

Amino-acid sequence (97 residues)

MDSSSSSSAA GLGAVDPQLQ HFIEVETQKQ RFQQLVHQMT ELCWEKCMDK PGPKLDSRAE ACFVNCVERF IDTSQFILNR LEQTQKSKPV FSESLSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A)