About Protein phosphatase 1 regulatory subunit 12B
Protein phosphatase 1 regulatory subunit 12B (PPP1R12B) is a protein
from Homo sapiens identified by UniProt accession
O60237, 982 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 12B |
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| UniProt accession | O60237 |
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| Gene | PPP1R12B |
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| Organism | Homo sapiens |
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| Length | 982 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (57)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.23
- breast adenocarcinoma · score 0.23
- acne · score 0.18
- serum albumin measurement · score 0.17
- sex ratio · score 0.16
- Congenital lactic acidosis · score 0.11
- cortical surface area measurement · score 0.09
- bilirubin measurement · score 0.06
- mean corpuscular volume · score 0.05
- platelet count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60237-F1 | alphafold | PREDICTED | 62.26 | — |
Amino-acid sequence (982 residues)
MAELEHLGGK RAESARMRRA EQLRRWRGSL TEQEPAERRG AGRQPLTRRG SPRVRFEDGA VFLAACSSGD TDEVRKLLAR GADINTVNVD GLTALHQACI DENLDMVKFL VENRANVNQQ DNEGWTPLHA AASCGYLNIA EYFINHGASV GIVNSEGEVP SDLAEEPAMK DLLLEQVKKQ GVDLEQSRKE EEQQMLQDAR QWLNSGKIED VRQARSGATA LHVAAAKGYS EVLRLLIQAG YELNVQDYDG WTPLHAAAHW GVKEACSILA EALCDMDIRN KLGQTPFDVA DEGLVEHLEL LQKKQNVLRS EKETRNKLIE SDLNSKIQSG FFKNKEKMLY EEETPKSQEM EEENKESSSS SSEEEEGEDE ASESETEKEA DKKPEAFVNH SNSESKSSIT EQIPAPAQNT FSASSARRFS SGLFNKPEEP KDESPSSWRL GLRKTGSHNM LSEVANSREP IRDRGSSIYR SSSSPRISAL LDNKDKEREN KSYISSLAPR KLNSTSDIEE KENRESAVNL VRSGSYTRQL WRDEAKGNEI PQTIAPSTYV STYLKRTPHK SQADTTAEKT ADNVSSSTPL CVITNRPLPS TANGVTATPV LSITGTDSSV EAREKRRSYL TPVRDEEAES LRKARSRQAR QTRRSTQGVT LTDLQEAERT FSRSRAERQA QEQPREKPTD TEGLEGSPEK HEPSAVPATE AGEGQQPWGR SLDEEPICHR LRCPAQPDKP TTPASPSTSR PSLYTSSHLL WTNRFSVPDS ESSETTTNTT TAKEMDKNEN EEADLDEQSS KRLSIRERRR PKERRRGTGI NFWTKDEDET DGSEEVKETW HERLSRLESG GSNPTTSDSY GDRASARARR EAREARLATL TSRVEEDSNR DYKKLYESAL TENQKLKTKL QEAQLELADI KSKLEKVAQQ KQEKTSDRSS VLEMEKRERR ALERKMSEME EEMKVLTELK SDNQRLKDEN GALIRVISKL SK
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