SH3 domain-binding protein 5 (SH3BP5)

About SH3 domain-binding protein 5

SH3 domain-binding protein 5 (SH3BP5) is a protein from Homo sapiens identified by UniProt accession O60239, 455 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.

Target properties

Protein name	SH3 domain-binding protein 5
UniProt accession	O60239
Gene	SH3BP5
Organism	Homo sapiens
Length	455 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (133)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.30
diffuse plaque measurement · score 0.28
neurodegenerative disease · score 0.24
drug use measurement · score 0.13
mean platelet volume · score 0.12
apolipoprotein A 1 measurement · score 0.12
Melnick-Needles syndrome · score 0.08
pachyonychia congenita · score 0.08
acute myeloid leukemia · score 0.08
diffuse large B-cell lymphoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60239-F1	alphafold	PREDICTED	70.63	—

Amino-acid sequence (455 residues)

MDAALKRSRS EEPAEILPPA RDEEEEEEEG MEQGLEEEEE VDPRIQGELE KLNQSTDDIN RRETELEDAR QKFRSVLVEA TVKLDELVKK IGKAVEDSKP YWEARRVARQ AQLEAQKATQ DFQRATEVLR AAKETISLAE QRLLEDDKRQ FDSAWQEMLN HATQRVMEAE QTKTRSELVH KETAARYNAA MGRMRQLEKK LKRAINKSKP YFELKAKYYV QLEQLKKTVD DLQAKLTLAK GEYKMALKNL EMISDEIHER RRSSAMGPRG CGVGAEGSST SVEDLPGSKP EPDAISVASE AFEDDSCSNF VSEDDSETQS VSSFSSGPTS PSEMPDQFPA VVRPGSLDLP SPVSLSEFGM MFPVLGPRSE CSGASSPECE VERGDRAEGA ENKTSDKANN NRGLSSSSGS GGSSKSQSST SPEGQALENR MKQLSLQCSK GRDGIIADIK MVQIG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards