Perilipin-1 (PLIN1)

About Perilipin-1

Perilipin-1 (PLIN1) is a protein from Homo sapiens identified by UniProt accession O60240, 522 residues long. MolForge cross-references it against 0 known binders and 230 disease associations.

Target properties

Protein name	Perilipin-1
UniProt accession	O60240
Gene	PLIN1
Organism	Homo sapiens
Length	522 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (230)

Diseases linked to this target (Open Targets).

PLIN1-related familial partial lipodystrophy · score 0.71
high density lipoprotein cholesterol measurement · score 0.55
familial partial lipodystrophy, Dunnigan type · score 0.52
waist-hip ratio · score 0.50
BMI-adjusted waist-hip ratio · score 0.37
lipoprotein measurement · score 0.36
triglyceride measurement · score 0.35
triglyceride:HDL cholesterol ratio · score 0.31
reticulocyte count · score 0.29
BMI-adjusted waist circumference · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60240-F1	alphafold	PREDICTED	54.68	—

Amino-acid sequence (522 residues)

MAVNKGLTLL DGDLPEQENV LQRVLQLPVV SGTCECFQKT YTSTKEAHPL VASVCNAYEK GVQSASSLAA WSMEPVVRRL STQFTAANEL ACRGLDHLEE KIPALQYPPE KIASELKDTI STRLRSARNS ISVPIASTSD KVLGAALAGC ELAWGVARDT AEFAANTRAG RLASGGADLA LGSIEKVVEY LLPPDKEESA PAPGHQQAQK SPKAKPSLLS RVGALTNTLS RYTVQTMARA LEQGHTVAMW IPGVVPLSSL AQWGASVAMQ AVSRRRSEVR VPWLHSLAAA QEEDHEDQTD TEGEDTEEEE ELETEENKFS EVAALPGPRG LLGGVAHTLQ KTLQTTISAV TWAPAAVLGM AGRVLHLTPA PAVSSTKGRA MSLSDALKGV TDNVVDTVVH YVPLPRLSLM EPESEFRDID NPPAEVERRE AERRASGAPS AGPEPAPRLA QPRRSLRSAQ SPGAPPGPGL EDEVATPAAP RPGFPAVPRE KPKRRVSDSF FRPSVMEPIL GRTHYSQLRK KS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards