Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1)

About Heparan-sulfate 6-O-sulfotransferase 1

Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1) is a protein from Homo sapiens identified by UniProt accession O60243, 411 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	Heparan-sulfate 6-O-sulfotransferase 1
UniProt accession	O60243
Gene	HS6ST1
Organism	Homo sapiens
Length	411 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

Kallmann syndrome · score 0.44
hypogonadotropic hypogonadism · score 0.40
lymphocyte count · score 0.36
body height · score 0.31
heel bone mineral density · score 0.30
blood protein measurement · score 0.29
lymphocyte:monocyte ratio · score 0.26
lymphocyte percentage of leukocytes · score 0.25
brain measurement · score 0.20
age-related macular degeneration · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60243-F1	alphafold	PREDICTED	86.64	—

Amino-acid sequence (411 residues)

MRRRRAGGRT MVERASKFVL VVAGSVCFML ILYQYAGPGL SLGAPGGRAP PDDLDLFPTP DPHYEKKYYF PVRELERSLR FDMKGDDVIV FLHIQKTGGT TFGRHLVQNV RLEVPCDCRP GQKKCTCYRP NRRETWLFSR FSTGWSCGLH ADWTELTNCV PGVLDRRDSA ALRTPRKFYY ITLLRDPVSR YLSEWRHVQR GATWKTSLHM CDGRTPTPEE LPPCYEGTDW SGCTLQEFMD CPYNLANNRQ VRMLADLSLV GCYNLSFIPE GKRAQLLLES AKKNLRGMAF FGLTEFQRKT QYLFERTFNL KFIRPFMQYN STRAGGVEVD EDTIRRIEEL NDLDMQLYDY AKDLFQQRYQ YKRQLERREQ RLRSREERLL HRAKEALPRE DADEPGRVPT EDYMSHIIEK W

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards