About Phosphoribosyl pyrophosphate synthase-associated protein 2
Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPSAP2) is a protein
from Homo sapiens identified by UniProt accession
O60256, 369 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Phosphoribosyl pyrophosphate synthase-associated protein 2 |
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| UniProt accession | O60256 |
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| Gene | PRPSAP2 |
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| Organism | Homo sapiens |
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| Length | 369 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.19
- skin disorder caused by infection · score 0.16
- viral disease · score 0.16
- self reported educational attainment · score 0.08
- acheiropody · score 0.04
- acromesomelic dysplasia 2C, Hunter-Thompson type · score 0.03
- Acromesomelic dysplasia, Hunter-Thomson type · score 0.03
- acromesomelic dysplasia 2A · score 0.03
- Fuhrmann syndrome · score 0.03
- tibia, hypoplasia or aplasia of, with polydactyly · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60256-F1 | alphafold | PREDICTED | 87.36 | — |
Amino-acid sequence (369 residues)
MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPNRETR VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC AKSIIGVIPY FPYSKQCKMR KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR RIHNGESMSY LFRNIGLDD
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