About Kallikrein-8
Kallikrein-8 (KLK8) is a protein
from Homo sapiens identified by UniProt accession
O60259, 260 residues long.
MolForge cross-references it against 0 known binders and
195 disease associations.
Target properties
| Protein name | Kallikrein-8 |
|---|
| UniProt accession | O60259 |
|---|
| Gene | KLK8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 260 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (195)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.32
- breast adenocarcinoma · score 0.22
- prostate adenocarcinoma · score 0.21
- clear cell renal carcinoma · score 0.18
- gastric adenocarcinoma · score 0.16
- urinary bladder cancer · score 0.11
- endometrial cancer · score 0.10
- unipolar depression · score 0.08
- neoplasm · score 0.06
- cardiac hypertrophy · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60259-F1 | alphafold | PREDICTED | 88.88 | — |
Amino-acid sequence (260 residues)
MGRPRPRAAK TWMFLLLLGG AWAGHSRAQE DKVLGGHECQ PHSQPWQAAL FQGQQLLCGG VLVGGNWVLT AAHCKKPKYT VRLGDHSLQN KDGPEQEIPV VQSIPHPCYN SSDVEDHNHD LMLLQLRDQA SLGSKVKPIS LADHCTQPGQ KCTVSGWGTV TSPRENFPDT LNCAEVKIFP QKKCEDAYPG QITDGMVCAG SSKGADTCQG DSGGPLVCDG ALQGITSWGS DPCGRSDKPG VYTNICRYLD WIKKIIGSKG
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