About E3 ubiquitin-protein ligase parkin
E3 ubiquitin-protein ligase parkin (PRKN) is a protein
from Homo sapiens identified by UniProt accession
O60260, 465 residues long.
MolForge cross-references it against 0 known binders and
545 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase parkin |
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| UniProt accession | O60260 |
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| Gene | PRKN |
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| Organism | Homo sapiens |
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| Length | 465 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (545)
Diseases linked to this target (Open Targets).
- Young adult-onset Parkinsonism · score 0.82
- late-onset Parkinson disease · score 0.64
- young-onset Parkinson disease · score 0.60
- body mass index · score 0.52
- ovarian neoplasm · score 0.52
- ovarian cancer · score 0.52
- Dystonia · score 0.51
- lung cancer · score 0.50
- physical activity measurement · score 0.45
- Parkinson disease · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60260-F1 | alphafold | PREDICTED | 78.07 | — |
Amino-acid sequence (465 residues)
MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT CTDVRSPVLV FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV TCEGGNGLGC GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ ARWEAASKET IKKTTKPCPR CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG CEWNRVCMGD HWFDV
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