About E3 ubiquitin-protein ligase MGRN1
E3 ubiquitin-protein ligase MGRN1 (MGRN1) is a protein
from Homo sapiens identified by UniProt accession
O60291, 552 residues long.
MolForge cross-references it against 0 known binders and
171 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase MGRN1 |
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| UniProt accession | O60291 |
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| Gene | MGRN1 |
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| Organism | Homo sapiens |
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| Length | 552 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (171)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- high density lipoprotein cholesterol measurement · score 0.26
- sex hormone-binding globulin measurement · score 0.20
- hemoglobin measurement · score 0.19
- clear cell renal carcinoma · score 0.18
- triglyceride measurement · score 0.16
- body height · score 0.14
- testosterone measurement · score 0.13
- hematocrit · score 0.13
- alkaline phosphatase measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60291-F1 | alphafold | PREDICTED | 65.58 | — |
Amino-acid sequence (552 residues)
MGSILSRRIA GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE GYLFGENMDL NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY KDDADSPTED GDKPRVLYSL EFTFDADARV AITIYCQASE EFLNGRAVYS PKSPSLQSET VHYKRGVSQQ FSLPSFKIDF SEWKDDELNF DLDRGVFPVV IQAVVDEGDV VEVTGHAHVL LAAFEKHMDG SFSVKPLKQK QIVDRVSYLL QEIYGIENKN NQETKPSDDE NSDNSNECVV CLSDLRDTLI LPCRHLCLCT SCADTLRYQA NNCPICRLPF RALLQIRAVR KKPGALSPVS FSPVLAQSLE HDEHSCPFKK SKPHPASLAS KKPKRETNSD SVPPGYEPIS LLEALNGLRA VSPAIPSAPL YEEITYSGIS DGLSQASCPL AAIDHILDSS RQKGRPQSKA PDSTLRSPSS PIHEEDEEKL SEDVDAPPPL GGAELALRES SSPESFITEE VDESSSPQQG TRAASIENVL QDSSPEHCGR GPPADIYLPA LGPDSCSVGI DE
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