About Signal-induced proliferation-associated 1-like protein 3
Signal-induced proliferation-associated 1-like protein 3 (SIPA1L3) is a protein
from Homo sapiens identified by UniProt accession
O60292, 1781 residues long.
MolForge cross-references it against 0 known binders and
188 disease associations.
Target properties
| Protein name | Signal-induced proliferation-associated 1-like protein 3 |
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| UniProt accession | O60292 |
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| Gene | SIPA1L3 |
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| Organism | Homo sapiens |
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| Length | 1781 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (188)
Diseases linked to this target (Open Targets).
- early-onset non-syndromic cataract · score 0.47
- total early-onset cataract · score 0.37
- glomerular filtration rate · score 0.25
- eosinophil count · score 0.25
- serum gamma-glutamyl transferase measurement · score 0.24
- gut microbiome measurement · score 0.22
- taxonomic microbiome measurement · score 0.22
- appendicular lean mass · score 0.21
- mathematical ability · score 0.19
- prostate carcinoma · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60292-F1 | alphafold | PREDICTED | 55.52 | — |
Amino-acid sequence (1781 residues)
MTTYRAIPSD GVDLAASCGA RVGDVLPGPH TGDYAPLGFW AQNGSMSQPL GESPATATAT ATATTRPSPT TPAMPKMGVR ARVADWPPKR EALREHSNPS PSQDTDGTKA TKMAHSMRSI QNGQPPTSTP ASSGSKAFHR LSRRRSKDVE FQDGWPRSPG RAFLPLRHRS SSEITLSECD AEDAGEPRGA RHTGALPLFR EYGSTSSIDV QGMPEQSFFD ILNEFRSEQP DARGCQALTE LLRADPGPHL MGGGGGAKGD SHNGQPAKDS LLPLQPTKEK EKARKKPARG LGGGDTVDSS IFRKLRSSKP EGEAGRSPGE ADEGRSPPEA SRPWVCQKSF AHFDVQSMLF DLNEAAANRV SVSQRRNTTT GASAASAASA MASLTASRAH SLGGLDPAFT STEDLNCKEN LEQDLGDDNS NDLLLSCPHF RNEIGGECER NVSFSRASVG SPSSGEGHLA EPALSAYRTN ASISVLEVPK EQQRTQSRPR QYSIEHVDLG ARYYQDYFVG KEHANYFGVD EKLGPVAVSI KREKLEDHKE HGPQYQYRII FRTRELITLR GSILEDATPT ATKHGTGRGL PLKDALEYVI PELNIHCLRL ALNTPKVTEQ LLKLDEQGLC RKHKVGILYC KAGQSSEEEM YNNEEAGPAF EEFLSLIGEK VCLKGFTKYA AQLDVKTDST GTHSLYTMYQ DYEIMFHVST LLPYTPNNRQ QLLRKRHIGN DIVTIIFQEP GALPFTPKNI RSHFQHVFII VRVHNPCTDN VCYSMAVTRS KDAPPFGPPI PSGTTFRKSD VFRDFLLAKV INAENAAHKS DKFHTMATRT RQEYLKDLAE NCVSNTPIDS TGKFNLISLT SKKKEKTKAR AGAEQHSAGA IAWRVVAQDY AQGVEIDCIL GISNEFVVLL DLRTKEVVFN CYCGDVIGWT PDSSTLKIFY GRGDHIFLQA TEGSVEDIRE IVQRLKVMTS GWETVDMTLR RNGLGQLGFH VKYDGTVAEV EDYGFAWQAG LRQGSRLVEI CKVAVVTLTH DQMIDLLRTS VTVKVVIIPP FEDGTPRRGW PETYDMNTSE PKTEQESITP GGRPPYRSNA PWQWSGPASH NSLPASKWAT PTTPGHAQSL SRPLKQTPIV PFRESQPLHS KRPVSFPETP YTVSPAGADR VPPYRQPSGS FSTPGSATYV RYKPSPERYT AAPHPLLSLD PHFSHDGTSS GDSSSGGLTS QESTMERQKP EPLWHVPAQA RLSAIAGSSG NKHPSRQDAA GKDSPNRHSK GEPQYSSHSS SNTLSSNASS SHSDDRWFDP LDPLEPEQDP LSKGGSSDSG IDTTLYTSSP SCMSLAKAPR PAKPHKPPGS MGLCGGGREA AGRSHHADRR REVSPAPAVA GQSKGYRPKL YSSGSSTPTG LAGGSRDPPR QPSDMGSRVG YPAQVYKTAS AETPRPSQLA QPSPFQLSAS VPKSFFSKQP VRNKHPTGWK RTEEPPPRPL PFSDPKKQVD TNTKNVFGQP RLRASLRDLR SPRKNYKSTI EDDLKKLIIM DNLGPEQERD TGQSPQKGLQ RTLSDESLCS GRREPSFASP AGLEPGLPSD VLFTSTCAFP SSTLPARRQH QHPHPPVGPG ATPAAGSGFP EKKSTISASE LSLADGRDRP LRRLDPGLMP LPDTAAGLEW SSLVNAAKAY EVQRAVSLFS LNDPALSPDI PPAHSPVHSH LSLERGPPTP RTTPTMSEEP PLDLTGKVYQ LEVMLKQLHT DLQKEKQDKV VLQSEVASLR QNNQRLQEES QAASEQLRKF AEIFCREKKE L
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