About Leucine-rich repeat-containing protein 37A3
Leucine-rich repeat-containing protein 37A3 (LRRC37A3) is a protein
from Homo sapiens identified by UniProt accession
O60309, 1634 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 37A3 |
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| UniProt accession | O60309 |
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| Gene | LRRC37A3 |
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| Organism | Homo sapiens |
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| Length | 1634 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- visual perception measurement · score 0.24
- white matter microstructure measurement · score 0.16
- neuroimaging measurement · score 0.15
- brain volume measurement · score 0.12
- cortical thickness · score 0.12
- Familial prostate cancer · score 0.11
- prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- brain measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60309-F1 | alphafold | PREDICTED | 42.33 | — |
Amino-acid sequence (1634 residues)
MTSAQCPALA CVMSPLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPEPW SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGELP LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGIIHQL STPQSQKQTL QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ QQPVQPSESS REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT QATVQPLDLG FTITPESMTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP LDLELTITTK PTTEVKPSPT TEETSTQLPD LGLAIIPEPT TETGHSTALE KTTAPRPDRV QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIV PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY TSTELIIEPE EPSDSSGINL SGFGSEQLDT NDESDVTSTL SYILPYFSAV NLDVKSLLLP FIKLPTTGNS LAKIQTVGKN RQRLNRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENT AEEKRLGSPA PRELKQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGAPSTSS PAKALPQVRD RWKDLTHAIS ILESAKARVT NMKTSKPIVH SRKKYRFHKT RSRMTHRTPK VKKSPKVRKK SYLSRLMLSN RLPFSAAKSL INSPSQGAFS SLRDLSPQEN PFLEVSAPSE HFIENNNTKD TTARNAFEEN VFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSVIPNNNV RRLIAHVIRT LKMDCSGAHV QVTCAKLVSR TGHLMKLLSG QQEVKASKIE WDTDQWKTEN YINESTEAQS EQKEKSLEFT KELPGYGYTK KLILALIVTG ILTILIILLC LIEICCHRRS LQEDEEGFSR DSEAPTEEES EALP
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