About Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C) is a protein
from Homo sapiens identified by UniProt accession
O60331, 668 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma |
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| UniProt accession | O60331 |
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| Gene | PIP5K1C |
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| Organism | Homo sapiens |
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| Length | 668 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (56)
Diseases linked to this target (Open Targets).
- Neurodevelopmental disorder · score 0.51
- Lethal congenital contracture syndrome type 3 · score 0.50
- lethal congenital contracture syndrome 3 · score 0.48
- Intellectual disability · score 0.37
- epilepsy · score 0.37
- neuroinflammatory disorder · score 0.36
- glioblastoma multiforme · score 0.29
- breast adenocarcinoma · score 0.29
- ovarian cancer · score 0.28
- neurodegenerative disease · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60331-F1 | alphafold | PREDICTED | 63.82 | — |
Amino-acid sequence (668 residues)
MELEVPDEAE SAEAGAVPSE AAWAAESGAA AGLAQKKAAP TEVLSMTAQP GPGHGKKLGH RGVDASGETT YKKTTSSTLK GAIQLGIGYT VGHLSSKPER DVLMQDFYVV ESIFFPSEGS NLTPAHHFQD FRFKTYAPVA FRYFRELFGI RPDDYLYSLC NEPLIELSNP GASGSLFYVT SDDEFIIKTV MHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCVQSGG KNIRVVVMNN ILPRVVKMHL KFDLKGSTYK RRASKKEKEK SFPTYKDLDF MQDMPEGLLL DADTFSALVK TLQRDCLVLE SFKIMDYSLL LGVHNIDQHE RERQAQGAQS TSDEKRPVGQ KALYSTAMES IQGGAARGEA IESDDTMGGI PAVNGRGERL LLHIGIIDIL QSYRFIKKLE HTWKALVHDG DTVSVHRPSF YAERFFKFMS NTVFRKNSSL KSSPSKKGRG GALLAVKPLG PTAAFSASQI PSEREEAQYD LRGARSYPTL EDEGRPDLLP CTPPSFEEAT TASIATTLSS TSLSIPERSP SETSEQPRYR RRTQSSGQDG RPQEEPPAEE DLQQITVQVE PACSVEIVVP KEEDAGVEAS PAGASAAVEV ETASQASDEE GAPASQASDE EDAPATDIYF PTDERSWVYS PLHYSAQAPP ASDGESDT
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