About Mitogen-activated protein kinase-binding protein 1
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) is a protein
from Homo sapiens identified by UniProt accession
O60336, 1514 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase-binding protein 1 |
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| UniProt accession | O60336 |
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| Gene | MAPKBP1 |
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| Organism | Homo sapiens |
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| Length | 1514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (69)
Diseases linked to this target (Open Targets).
- nephronophthisis · score 0.71
- Microcephaly - brain defect - spasticity - hypernatremia · score 0.37
- Juvenile nephronophthisis · score 0.37
- late-onset nephronophthisis · score 0.37
- neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies · score 0.37
- neurodegenerative disease · score 0.33
- genetic disorder · score 0.19
- BMI-adjusted waist-hip ratio · score 0.19
- waist-hip ratio · score 0.15
- diastolic blood pressure · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60336-F1 | alphafold | PREDICTED | 62.04 | — |
Amino-acid sequence (1514 residues)
MAVEGSTITS RIKNLLRSPS IKLRRSKAGN RREDLSSKVT LEKVLGITVS GGRGLACDPR SGLVAYPAGC VVVLFNPRKH KQHHILNSSR KTITALAFSP DGKYLVTGES GHMPAVRVWD VAEHSQVAEL QEHKYGVACV AFSPSAKYIV SVGYQHDMIV NVWAWKKNIV VASNKVSSRV TAVSFSEDCS YFVTAGNRHI KFWYLDDSKT SKVNATVPLL GRSGLLGELR NNLFTDVACG RGKKADSTFC ITSSGLLCEF SDRRLLDKWV ELRNIDSFTT TVAHCISVSQ DYIFCGCADG TVRLFNPSNL HFLSTLPRPH ALGTDIASVT EASRLFSGVA NARYPDTIAL TFDPTNQWLS CVYNDHSIYV WDVRDPKKVG KVYSALYHSS CVWSVEVYPE VKDSNQACLP PSSFITCSSD NTIRLWNTES SGVHGSTLHR NILSSDLIKI IYVDGNTQAL LDTELPGGDK ADASLLDPRV GIRSVCVSPN GQHLASGDRM GTLRVHELQS LSEMLKVEAH DSEILCLEYS KPDTGLKLLA SASRDRLIHV LDAGREYSLQ QTLDEHSSSI TAVKFAASDG QVRMISCGAD KSIYFRTAQK SGDGVQFTRT HHVVRKTTLY DMDVEPSWKY TAIGCQDRNI RIFNISSGKQ KKLFKGSQGE DGTLIKVQTD PSGIYIATSC SDKNLSIFDF SSGECVATMF GHSEIVTGMK FSNDCKHLIS VSGDSCIFVW RLSSEMTISM RQRLAELRQR QRGGKQQGPS SPQRASGPNR HQAPSMLSPG PALSSDSDKE GEDEGTEEEL PALPVLAKST KKALASVPSP ALPRSLSHWE MSRAQESVGF LDPAPAANPG PRRRGRWVQP GVELSVRSML DLRQLETLAP SLQDPSQDSL AIIPSGPRKH GQEALETSLT SQNEKPPRPQ ASQPCSYPHI IRLLSQEEGV FAQDLEPAPI EDGIVYPEPS DNPTMDTSEF QVQAPARGTL GRVYPGSRSS EKHSPDSACS VDYSSSCLSS PEHPTEDSES TEPLSVDGIS SDLEEPAEGD EEEEEEEGGM GPYGLQEGSP QTPDQEQFLK QHFETLASGA APGAPVQVPE RSESRSISSR FLLQVQTRPL REPSPSSSSL ALMSRPAQVP QASGEQPRGN GANPPGAPPE VEPSSGNPSP QQAASVLLPR CRLNPDSSWA PKRVATASPF SGLQKAQSVH SLVPQERHEA SLQAPSPGAL LSREIEAQDG LGSLPPADGR PSRPHSYQNP TTSSMAKISR SISVGENLGL VAEPQAHAPI RVSPLSKLAL PSRAHLVLDI PKPLPDRPTL AAFSPVTKGR APGEAEKPGF PVGLGKAHST TERWACLGEG TTPKPRTECQ AHPGPSSPCA QQLPVSSLFQ GPENLQPPPP EKTPNPMECT KPGAALSQDS EPAVSLEQCE QLVAELRGSV RQAVRLYHSV AGCKMPSAEQ SRIAQLLRDT FSSVRQELEA VAGAVLSSPG SSPGAVGAEQ TQALLEQYSE LLLRAVERRM ERKL
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