About TBC1 domain family member 12
TBC1 domain family member 12 (TBC1D12) is a protein
from Homo sapiens identified by UniProt accession
O60347, 775 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | TBC1 domain family member 12 |
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| UniProt accession | O60347 |
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| Gene | TBC1D12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 775 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (80)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.28
- mean corpuscular volume · score 0.25
- Red cell distribution width · score 0.23
- myeloid white cell count · score 0.21
- erythrocyte count · score 0.20
- platelet count · score 0.20
- red blood cell density measurement · score 0.18
- body fat percentage · score 0.18
- mean reticulocyte volume · score 0.16
- leukocyte count · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60347-F1 | alphafold | PREDICTED | 62.92 | — |
Amino-acid sequence (775 residues)
MVGPEDAGAC SGRNPKLLPV PAPDPVGQDR KVIRATGGFG GGVGAVEPPE EADEEEEADE EEETPPRQLL QRYLAAAGEQ LEPGLCYCPL PAGQAGAPPP SAAPRSDACL LGSGSKHRGA EVADGRAPRH EGMTNGDSGF LPGRDCRDLE EARGLARAGG RESRRRRPYG RLRLEGPGDE DADGAGSPSD WASPLEDPLR SCCLVAADAQ EPEGAGSDSG DSPASSCSSS EDSEQRGVGA GGPEEGAPPA TSAERTNGGA EPRLGFSDIH FNSRNTFQVS RGQSARDHLP PAGPPVPLPA AEQGPAGASA RARRSGGFAD FFTRNLFPKR TKELKSVVHS APGWKLFGKV PPRENLQKTS KIIQQEYEAR TGRTCKPPPQ SSRRKNFEFE PLSTTALILE DRPSNLPAKS VEEALRHRQE YDEMVAEAKK REIKEAHKRK RIMKERFKQE ENIASAMVIW INEILPNWEV MRSTRRVREL WWQGLPPSVR GKVWSLAVGN ELNITPELYE IFLSRAKERW KSFSETSSEN DTEGVSVADR EASLELIKLD ISRTFPSLYI FQKGGPYHDV LHSILGAYTC YRPDVGYVQG MSFIAAVLIL NLEEADAFIA FANLLNKPCQ LAFFRVDHSM MLKYFATFEV FFEENLSKLF LHFKSYSLTP DIYLIDWIFT LYSKSLPLDL ACRVWDVFCR DGEEFLFRTG LGILRLYEDI LLQMDFIHIA QFLTKLPEDI TSEKLFSCIA AIQMQNSTKK WTQVFASVMK DIKEGDKNSS PALKS
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