About HMG box-containing protein 1
HMG box-containing protein 1 (HBP1) is a protein
from Homo sapiens identified by UniProt accession
O60381, 514 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | HMG box-containing protein 1 |
|---|
| UniProt accession | O60381 |
|---|
| Gene | HBP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 514 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- cystatin C measurement · score 0.24
- serum albumin measurement · score 0.21
- COG5-congenital disorder of glycosylation · score 0.18
- monocyte count · score 0.18
- type 1 diabetes mellitus · score 0.17
- congenital disorder of glycosylation · score 0.12
- high density lipoprotein cholesterol measurement · score 0.11
- urate measurement · score 0.11
- apolipoprotein A 1 measurement · score 0.09
- alkaline phosphatase measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60381-F1 | alphafold | PREDICTED | 61.58 | — |
Amino-acid sequence (514 residues)
MVWEVKTNQM PNAVQKLLLV MDKRASGMND SLELLQCNEN LPSSPGYNSC DEHMELDDLP ELQAVQSDPT QSGMYQLSSD VSHQEYPRSS WNQNTSDIPE TTYRENEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA RPPPVSSSSK SEPAFPHHHW KEETPVRHER ANSESESGIF CMSSLSDDDD LGWCNSWPST VWHCFLKGTR LCFHKGSNKE WQDVEDFARA EGCDNEEDLQ MGIHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH PFYVKNKGWS SFYPSLTVVQ HGIPCCEVHI GDVCLPPGHP DAINFDDSGV FDTFKSYDFT PMDSSAVYVL SSMARQRRAS LSCGGPGGQD FARSGFSKNC GSPGSSQLSS NSLYAKAVKN HSSGTVSATS PNKCKRPMNA FMLFAKKYRV EYTQMYPGKD NRAISVILGD RWKKMKNEER RMYTLEAKAL AEEQKRLNPD CWKRKRTNSG SQQH
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