About Growth/differentiation factor 9
Growth/differentiation factor 9 (GDF9) is a protein
from Homo sapiens identified by UniProt accession
O60383, 454 residues long.
MolForge cross-references it against 0 known binders and
164 disease associations.
Target properties
| Protein name | Growth/differentiation factor 9 |
|---|
| UniProt accession | O60383 |
|---|
| Gene | GDF9 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 454 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (164)
Diseases linked to this target (Open Targets).
- 46,XX gonadal dysgenesis · score 0.70
- genetic non-acquired premature ovarian failure · score 0.33
- primary ovarian insufficiency · score 0.22
- Isolated CoQ-cytochrome C reductase deficiency · score 0.15
- mitochondrial complex III deficiency nuclear type 1 · score 0.12
- polycystic ovary syndrome · score 0.12
- myeloid white cell count · score 0.07
- Testicular regression syndrome · score 0.07
- 46,XY complete gonadal dysgenesis · score 0.06
- 46,XX testicular disorder of sex development · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60383-F1 | alphafold | PREDICTED | 66.24 | — |
Amino-acid sequence (454 residues)
MARPNKFLLW FCCFAWLCFP ISLGSQASGG EAQIAASAEL ESGAMPWSLL QHIDERDRAG LLPALFKVLS VGRGGSPRLQ PDSRALHYMK KLYKTYATKE GIPKSNRSHL YNTVRLFTPC TRHKQAPGDQ VTGILPSVEL LFNLDRITTV EHLLKSVLLY NINNSVSFSS AVKCVCNLMI KEPKSSSRTL GRAPYSFTFN SQFEFGKKHK WIQIDVTSLL QPLVASNKRS IHMSINFTCM KDQLEHPSAQ NGLFNMTLVS PSLILYLNDT SAQAYHSWYS LHYKRRPSQG PDQERSLSAY PVGEEAAEDG RSSHHRHRRG QETVSSELKK PLGPASFNLS EYFRQFLLPQ NECELHDFRL SFSQLKWDNW IVAPHRYNPR YCKGDCPRAV GHRYGSPVHT MVQNIIYEKL DSSVPRPSCV PAKYSPLSVL TIEPDGSIAY KEYEDMIATK CTCR
Explore Growth/differentiation factor 9 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets