About Homeobox protein NOBOX
Homeobox protein NOBOX (NOBOX) is a protein
from Homo sapiens identified by UniProt accession
O60393, 691 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Homeobox protein NOBOX |
|---|
| UniProt accession | O60393 |
|---|
| Gene | NOBOX |
|---|
| Organism | Homo sapiens |
|---|
| Length | 691 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.78
- genetic non-acquired premature ovarian failure · score 0.49
- premature menopause · score 0.37
- Premature ovarian insufficiency · score 0.37
- genetic disorder · score 0.19
- hereditary breast carcinoma · score 0.11
- diet measurement · score 0.06
- breast carcinoma · score 0.06
- 46,XX gonadal dysgenesis · score 0.06
- 46,XX testicular disorder of sex development · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60393-F1 | alphafold | PREDICTED | 47.53 | — |
Amino-acid sequence (691 residues)
MALLLTLTSP DLEGTWDTRD KDGFKAQEGP PLAVPEFPVC GLYRIYGVCG SFSSFFIIRC SLCALETLKS PQHDPLEIPE QSLKLIPLVS GKRELTRGQK AGEKPLAAGP GEEELLRGSA PHAQDTQSEE LPPSCTISGE KKPPAVSGEA TGADAGRLCP PPRSRAPHKD RTLARSRPQT QGEDCSLPVG EVKIGKRSYS PAPGKQKKPN AMGLAPTSSP GAPNSARATH NPVPCGSGRG PCHLANLLST LAQSNQNRDH KQGPPEVTCQ IRKKTRTLYR SDQLEELEKI FQEDHYPDSD KRREIAQTVG VTPQRIMVKG AGSLVAGWSG GGPTIETLEL QSERSAVAWV WFQNRRAKWR KMEKLNGKES KDNPAAPGPA SSQCSSAAEI LPAVPMEPKP DPFPQESPLD TFPEPPMLLT SDQTLAPTQP SEGAQRVVTP PLFSPPPVRR ADLPFPLGPV HTPQLMPLLM DVAGSDSSHK DGPCGSWGTS ITLPPPCSYL EELEPQDYQQ SNQPGPFQFS QAPQPPLFQS PQPKLPYLPT FPFSMPSSLT LPPPEDSLFM FPCGPSGGTS QGYCPGASSG QILMQPPAGN IGTASWSDPC LPELPFPGPF CPQALGHPPG GDGYFPDLFP TPCPQALGRQ PSSALSWMPE GARPGTGPLL SKAKEEPPAA SLDQPSALEE ARGDDKNSHV P
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