One cut domain family member 3 (ONECUT3)

About One cut domain family member 3

One cut domain family member 3 (ONECUT3) is a protein from Homo sapiens identified by UniProt accession O60422, 494 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	One cut domain family member 3
UniProt accession	O60422
Gene	ONECUT3
Organism	Homo sapiens
Length	494 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
visual perception measurement · score 0.28
myelodysplastic syndrome · score 0.07
Barrett's esophagus · score 0.06
esophageal adenocarcinoma · score 0.04
mean corpuscular volume · score 0.02
cancer · score 0.02
neoplasm · score 0.01
colorectal adenocarcinoma · score 0.01
non-small cell lung carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60422-F1	alphafold	PREDICTED	56.85	—

Amino-acid sequence (494 residues)

MELSLESLGG LHSVAHAQAG ELLSPGHARS AAAQHRGLVA PGRPGLVAGM ASLLDGGGGG GGGGAGGAGG AGSAGGGADF RGELAGPLHP AMGMACEAPG LGGTYTTLTP LQHLPPLAAV ADKFHQHAAA AAVAGAHGGH PHAHPHPAAA PPPPPPPQRL AASVSGSFTL MRDERAALAS VGHLYGPYGK ELPAMGSPLS PLPNALPPAL HGAPQPPPPP PPPPLAAYGP PGHLAGDKLL PPAAFEPHAA LLGRAEDALA RGLPGGGGGT GSGGAGSGSA AGLLAPLGGL AAAGAHGPHG GGGGPGGSGG GPSAGAAAEE INTKEVAQRI TAELKRYSIP QAIFAQRILC RSQGTLSDLL RNPKPWSKLK SGRETFRRMW KWLQEPEFQR MSALRLAACK RKEQEQQKER ALQPKKQRLV FTDLQRRTLI AIFKENKRPS KEMQVTISQQ LGLELNTVSN FFMNARRRCM NRWAEEPSTA PGGPAGATAT FSKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards