About Phospholipid-transporting ATPase IK
Phospholipid-transporting ATPase IK (ATP8B3) is a protein
from Homo sapiens identified by UniProt accession
O60423, 1300 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | Phospholipid-transporting ATPase IK |
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| UniProt accession | O60423 |
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| Gene | ATP8B3 |
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| Organism | Homo sapiens |
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| Length | 1300 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (77)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.29
- Red cell distribution width · score 0.22
- glioblastoma multiforme · score 0.14
- breast adenocarcinoma · score 0.10
- systolic blood pressure · score 0.08
- body mass index · score 0.08
- Rare genetic female infertility · score 0.07
- Female infertility due to fertilization defect · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- female infertility due to oocyte meiotic arrest · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60423-F1 | alphafold | PREDICTED | 74.96 | — |
Amino-acid sequence (1300 residues)
MGTGPAQTPR STRAGPEPSP APPGPGDTGD SDVTQEGSGP AGIRGGETVI RAGMGDSPGR GAPERRHKAQ PGRARKYEWR PEGPTSMGSL GQREDLQDED RNSAFTWKVQ ANNRAYNGQF KEKVILCWQR KKYKTNVIRT AKYNFYSFLP LNLYEQFHRV SNLFFLIIII LQSIPDISTL PWFSLSTPMV CLLFIRATRD LVDDMGRHKS DRAINNRPCQ ILMGKSFKQK KWQDLCVGDV VCLRKDNIVP ADMLLLASTE PSSLCYVETV DIDGETNLKF RQALMVTHKE LATIKKMASF QGTVTCEAPN SRMHHFVGCL EWNDKKYSLD IGNLLLRGCR IRNTDTCYGL VIYAGFDTKI MKNCGKIHLK RTKLDLLMNK LVVVIFISVV LVCLVLAFGF GFSVKEFKDH HYYLSGVHGS SVAAESFFVF WSFLILLSVT IPMSMFILSE FIYLGNSVFI DWDVQMYYKP QDVPAKARST SLNDHLGQVE YIFSDKTGTL TQNILTFNKC CISGRVYGPD SEATTRPKEN PYLWNKFADG KLLFHNAALL HLVRTNGDEA VREFWRLLAI CHTVMVRESP RERPDQLLYQ AASPDEGALV TAARNFGYVF LSRTQDTVTI MELGEERVYQ VLAIMDFNST RKRMSVLVRK PEGAICLYTK GADTVIFERL HRRGAMEFAT EEALAAFAQE TLRTLCLAYR EVAEDIYEDW QQRHQEASLL LQNRAQALQQ LLGATAIEDR LQDGVPETIK CLKKSNIKIW VLTGDKQETA VNIGFACELL SENMLILEEK EISRILETYW ENSNNLLTRE SLSQVKLALV INGDFLDKLL VSLRKEPRAL AQNVNMDEAW QELGQSRRDF LYARRLSLLC RRFGLPLAAP PAQDSRARRS SEVLQERAFV DLASKCQAVI CCRVTPKQKA LIVALVKKYH QVVTLAIGDG ANDINMIKTA DVGVGLAGQE GMQAVQNSDF VLGQFCFLQR LLLVHGRWSY VRICKFLRYF FYKSMASMMV QVWFACYNGF TGQPLYEGWF LALFNLLYST LPVLYIGLFE QDVSAEQSLE KPELYVVGQK DELFNYWVFV QAIAHGVTTS LVNFFMTLWI SRDTAGPASF SDHQSFAVVV ALSCLLSITM EVILIIKYWT ALCVATILLS LGFYAIMTTT TQSFWLFRVS PTTFPFLYAD LSVMSSPSIL LVVLLSVSIN TFPVLALRVI FPALKELRAK EEKVEEGPSE EIFTMEPLPH VHRESRARRS SYAFSHREGY ANLITQGTIL RRGPGVSSDI ASESLDPSDE EAASSPKESQ
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