Acyl-CoA (8-3)-desaturase (FADS1)

About Acyl-CoA (8-3)-desaturase

Acyl-CoA (8-3)-desaturase (FADS1) is a protein from Homo sapiens identified by UniProt accession O60427, 444 residues long. MolForge cross-references it against 0 known binders and 331 disease associations.

Target properties

Protein name	Acyl-CoA (8-3)-desaturase
UniProt accession	O60427
Gene	FADS1
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (331)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
Red cell distribution width · score 0.39
serum metabolite measurement · score 0.39
platelet count · score 0.39
phosphatidylcholine measurement · score 0.38
low density lipoprotein cholesterol measurement · score 0.36
blood metabolite measurement · score 0.36
glycerophospholipid measurement · score 0.34
mean platelet volume · score 0.34
lysophosphatidylcholine measurement · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60427-F1	alphafold	PREDICTED	94.40	—

Amino-acid sequence (444 residues)

MAPDPVAAET AAQGPTPRYF TWDEVAQRSG CEERWLVIDR KVYNISEFTR RHPGGSRVIS HYAGQDATDP FVAFHINKGL VKKYMNSLLI GELSPEQPSF EPTKNKELTD EFRELRATVE RMGLMKANHV FFLLYLLHIL LLDGAAWLTL WVFGTSFLPF LLCAVLLSAV QAQAGWLQHD FGHLSVFSTS KWNHLLHHFV IGHLKGAPAS WWNHMHFQHH AKPNCFRKDP DINMHPFFFA LGKILSVELG KQKKKYMPYN HQHKYFFLIG PPALLPLYFQ WYIFYFVIQR KKWVDLAWMI TFYVRFFLTY VPLLGLKAFL GLFFIVRFLE SNWFVWVTQM NHIPMHIDHD RNMDWVSTQL QATCNVHKSA FNDWFSGHLN FQIEHHLFPT MPRHNYHKVA PLVQSLCAKH GIEYQSKPLL SAFADIIHSL KESGQLWLDA YLHQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards