About Gasdermin-E
Gasdermin-E (GSDME) is a protein
from Homo sapiens identified by UniProt accession
O60443, 496 residues long.
MolForge cross-references it against 0 known binders and
247 disease associations.
Target properties
| Protein name | Gasdermin-E |
|---|
| UniProt accession | O60443 |
|---|
| Gene | GSDME |
|---|
| Organism | Homo sapiens |
|---|
| Length | 496 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (247)
Diseases linked to this target (Open Targets).
- autosomal dominant nonsyndromic hearing loss · score 0.67
- deafness · score 0.53
- schizophrenia · score 0.44
- bipolar disorder · score 0.44
- self reported educational attainment · score 0.43
- depressive symptom measurement · score 0.42
- neuroticism measurement · score 0.41
- unipolar depression · score 0.40
- wellbeing measurement · score 0.40
- head and neck squamous cell carcinoma · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60443-F1 | alphafold | PREDICTED | 77.46 | — |
Amino-acid sequence (496 residues)
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL LCITLNGLCA LGREHS
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