About Ecotropic viral integration site 5 protein homolog
Ecotropic viral integration site 5 protein homolog (EVI5) is a protein
from Homo sapiens identified by UniProt accession
O60447, 810 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Ecotropic viral integration site 5 protein homolog |
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| UniProt accession | O60447 |
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| Gene | EVI5 |
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| Organism | Homo sapiens |
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| Length | 810 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (73)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- low density lipoprotein cholesterol measurement · score 0.28
- monocyte count · score 0.27
- multiple sclerosis · score 0.24
- total cholesterol measurement · score 0.23
- alkaline phosphatase measurement · score 0.22
- body mass index · score 0.22
- allergic disease · score 0.20
- asthma · score 0.20
- triglyceride measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60447-F1 | alphafold | PREDICTED | 74.14 | — |
Amino-acid sequence (810 residues)
MVTNKMTAAF RNPSGKQVAT DKVAEKLSST LSWVKNTVSH TVSQMASQVA SPSTSLHTTS SSTTLSTPAL SPSSPSQLSP DDLELLAKLE EQNRLLETDS KSLRSVNGSR RNSGSSLVSS SSASSNLSHL EEDSWILWGR IVNEWEDVRK KKEKQVKELV HKGIPHHFRA IVWQLLCSAQ SMPIKDQYSE LLKMTSPCEK LIRRDIARTY PEHNFFKEKD SLGQEVLFNV MKAYSLVDRE VGYCQGSAFI VGLLLMQMPE EEAFCVFVKL MQDYRLRELF KPSMAELGLC MYQFECMIQE HLPELFVHFQ SQSFHTSMYA SSWFLTIFLT TFPLPIATRI FDIFMSEGLE IVFRVGLALL QMNQAELMQL DMEGMLQHFQ KVIPHQFDGV PDKLIQAAYQ VKYNSKKMKK LEKEYTTIKT KEMEEQVEIK RLRTENRLLK QRIETLEKHK CSSNYNEDFV LQLEKELVQA RLSEAESQCA LKEMQDKVLD IEKRNNSLPD ENNIARLQEE LIAVKLREAE AIMGLKELRQ QVKDLEEHWQ RHLARTTGRW KDPPKKNAMN ELQDELMTIR LREAETQAEI REIKQRMMEM ETQNQINSNH LRRAEQEVIS LQEKVQYLSA QNKGLLTQLS EAKRKQAEIE CKNKEEVMAV RLREADSIAA VAELRQHIAE LEIQKEEGKL QGQLNKSDSN QYIGELKDQI AELNHELRCL KGQRGFSGQP PFDGIHIVNH LIGDDESFHS SDEDFIDNSL QETGVGFPLH GKSGSMSLDP AVADGSESET EDSVLETRES NQVVQKERPP RRRESYSTTV
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