About Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) is a protein
from Homo sapiens identified by UniProt accession
O60476, 641 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB |
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| UniProt accession | O60476 |
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| Gene | MAN1A2 |
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| Organism | Homo sapiens |
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| Length | 641 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (87)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.25
- self reported educational attainment · score 0.25
- alkaline phosphatase measurement · score 0.23
- leukocyte count · score 0.23
- smoking status measurement · score 0.20
- insomnia measurement · score 0.19
- mathematical ability · score 0.18
- brain volume measurement · score 0.09
- worry measurement · score 0.08
- surfactant metabolism dysfunction, pulmonary, 1 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60476-F1 | alphafold | PREDICTED | 85.28 | — |
Amino-acid sequence (641 residues)
MTTPALLPLS GRRIPPLNLG PPSFPHHRAT LRLSEKFILL LILSAFITLC FGAFFFLPDS SKHKRFDLGL EDVLIPHVDA GKGAKNPGVF LIHGPDEHRH REEEERLRNK IRADHEKALE EAKEKLRKSR EEIRAEIQTE KNKVVQEMKI KENKPLPPVP IPNLVGIRGG DPEDNDIREK REKIKEMMKH AWDNYRTYGW GHNELRPIAR KGHSPNIFGS SQMGATIVDA LDTLYIMGLH DEFLDGQRWI EDNLDFSVNS EVSVFEVNIR FIGGLLAAYY LSGEEIFKIK AVQLAEKLLP AFNTPTGIPW AMVNLKSGVG RNWGWASAGS SILAEFGTLH MEFIHLSYLT GDLTYYKKVM HIRKLLQKMD RPNGLYPNYL NPRTGRWGQY HTSVGGLGDS FYEYLLKAWL MSDKTDHEAR KMYDDAIEAI EKHLIKKSRG GLTFIGEWKN GHLEKKMGHL ACFAGGMFAL GADGSRADKA GHYLELGAEI ARTCHESYDR TALKLGPESF KFDGAVEAVA VRQAEKYYIL RPEVIETYWY LWRFTHDPRY RQWGWEAALA IEKYCRVNGG FSGVKDVYSS TPTHDDVQQS FFLAETLKYL YLLFSGDDLL PLDHWVFNTE AHPLPVLHLA NTTLSGNPAV R
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