About BMP/retinoic acid-inducible neural-specific protein 1
BMP/retinoic acid-inducible neural-specific protein 1 (BRINP1) is a protein
from Homo sapiens identified by UniProt accession
O60477, 761 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | BMP/retinoic acid-inducible neural-specific protein 1 |
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| UniProt accession | O60477 |
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| Gene | BRINP1 |
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| Organism | Homo sapiens |
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| Length | 761 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (98)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.48
- smoking status measurement · score 0.45
- mathematical ability · score 0.37
- PHF-tau measurement · score 0.36
- attention deficit hyperactivity disorder · score 0.34
- antisocial behaviour measurement · score 0.33
- substance abuse · score 0.33
- smoking behavior · score 0.33
- smoking behaviour measurement · score 0.33
- neck injury · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60477-F1 | alphafold | PREDICTED | 77.42 | — |
Amino-acid sequence (761 residues)
MNWRFVELLY FLFIWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH SRSYLSFVER HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE FQRSIRLLGR RPTTQQFIDT IIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE KFVQSALSYI MCNGEGEYLC QNSQCRCQCA EEFPQCNCPI TDIQIMEYTL ANMAKSWAEA YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQN RYKLLQSATE AQRQKIQRTA RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN GFWGTFLESQ RSCVCHGSTT LCQRPIPCVI GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD LDFQDLELKY LLQKMDSRLY VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM VIGMSMRICQ MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW TLLLGNRWKT FFETVHIYLR SRTRLPTLLR NETGQGPVDL SDPSKRQFYI KISDVQVFGY SLRFNADLLR SAVQQVNQSY TQGGQFYSSS SVMLLLLDIR DRINRLAPPV APGKPQLDLF SCMLKHRLKL TNSEIIRVNH ALDLYNTEIL KQSDQMTAKL C
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