Integral membrane protein GPR137B (GPR137B)

About Integral membrane protein GPR137B

Integral membrane protein GPR137B (GPR137B) is a protein from Homo sapiens identified by UniProt accession O60478, 399 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Integral membrane protein GPR137B
UniProt accession	O60478
Gene	GPR137B
Organism	Homo sapiens
Length	399 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

C-reactive protein measurement · score 0.41
cortical surface area measurement · score 0.30
diastolic blood pressure · score 0.28
brain measurement · score 0.24
blood protein measurement · score 0.13
vertebral joint disease · score 0.07
ovarian carcinoma · score 0.03
Acute hepatic failure · score 0.02
juvenile idiopathic arthritis · score 0.01
atherosclerosis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60478-F1	alphafold	PREDICTED	68.92	—

Amino-acid sequence (399 residues)

MRPERPRPRG SAPGPMETPP WDPARNDSLP PTLTPAVPPY VKLGLTVVYT VFYALLFVFI YVQLWLVLRY RHKRLSYQSV FLFLCLFWAS LRTVLFSFYF KDFVAANSLS PFVFWLLYCF PVCLQFFTLT LMNLYFTQVI FKAKSKYSPE LLKYRLPLYL ASLFISLVFL LVNLTCAVLV KTGNWERKVI VSVRVAINDT LFVLCAVSLS ICLYKISKMS LANIYLESKG SSVCQVTAIG VTVILLYTSR ACYNLFILSF SQNKSVHSFD YDWYNVSDQA DLKNQLGDAG YVLFGVVLFV WELLPTTLVV YFFRVRNPTK DLTNPGMVPS HGFSPRSYFF DNPRRYDSDD DLAWNIAPQG LQGGFAPDYY DWGQQTNSFL AQAGTLQDST LDPDKPSLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards